Natural glucocorticoids induce survival and proliferation of murine bone marrow granulocytes without altering function
نویسندگان
چکیده
منابع مشابه
Natural glucocorticoids induce expansion of all developmental stages of murine bone marrow granulocytes without inhibiting function.
Natural glucocorticoids (Gc) produced during stress have profound effects on the immune system. It is well known that Gc induce apoptosis in precursor T and B cells, markedly altering lymphopoiesis. However, it has been noted that marrow myeloid cells expanded both in proportion and absolute numbers in the mouse after Gc exposure. Mice were implanted with a corticosterone (CS) tablet that incre...
متن کاملTLR5 signaling in murine bone marrow induces hematopoietic progenitor cell proliferation and aids survival from radiation.
Administration of the bacterial protein flagellin to mice activates innate immune signaling that protects against an array of challenges, including ionizing radiation. Herein, we define the underlying mechanism for this protection. We report that flagellin treatment induces proliferation and mobilization of bone marrow cells that aid survival following irradiation. Specifically, treatment of mi...
متن کاملInhibition of tumor cell proliferation by natural suppressor cells present in murine bone marrow.
Natural suppressor (NS) cells, which are Thy-1-, immunoglobulin-, and nonadherent cells with relatively low density (1.063 to 1.075 g/ml), inhibit not only the proliferation of spleen cells which have been stimulated by allogeneic cells or mitogens but also the proliferation of tumor cell lines. Cell-to-cell contact is not necessary for NS cells to exert NS activity. Being radioresistant, DNA s...
متن کاملKinetics of Cell Proliferation of Murine Bone Marrow Cells Cultured
Mouse bone marrow cells were cultured in diffusion chambers implanted in the abdominal cavity of host mice that were subjected to different kinds of treatment. Preirradiation of the chamber host enhanced the cell growth in the chambers as follows: the number of cells capable of proliferation and differentiation in the chambers (diffusion chamber progenitor cells, DCPC) as determined by a limiti...
متن کاملThe Role of Bone Marrow Aspiration and Bone Marrow Biopsy in Diagnosis of Bone Marrow Metastases
Background: Bone marrow is the site of many malignant disorders and it is one of the common places for solid tumors to metastasize. Examination of the bone marrow aspirate and biopsy is a routine procedure performed for assessment of various conditions such as cytopenias, hematologic neoplasms, nonmalignant disorders and metastatic neoplasms. Methods: The patients were referred to the Hema...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2008
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fasebj.22.1_supplement.844.10